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Tirzepatide
Tirzepatide is a once a week injectable peptide approved for treating type 2 diabetes and obesity that functions as a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist. By activating both incretin hormone pathways, Tirzepatide enhances glucose dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and significantly reduces appetite leading to substantial improvements in body weight and metabolic health. In the landmark SURMOUNT-1 Phase 3 clinical trial, adults with obesity or overweight without diabetes receiving the highest maintenance dose experienced an average 20.9% reduction in body weight after 72 weeks. Making Tirzepatide one of the most effective medications for chronic weight management. Additional clinical trials have demonstrated improvements in cardiometabolic risk factors and obstructive sleep apnea. Patients saw and experienced the best results with a 10mg maintenance dose with a 2.5mg start.
| Target Maintenance Dose | Dose Escalation Schedule |
| 5mg | Weeks 1–4: 2.5 mg → Weeks 5–72: 5 mg |
| 10mg | Weeks 1–4: 2.5 mg → Weeks 5–8: 5 mg → Weeks 9–12: 7.5 mg → Weeks 13–72: 10 mg |
| 15mg | Weeks 1–4: 2.5 mg → Weeks 5–8: 5 mg → Weeks 9–12: 7.5 mg → Weeks 13–16: 10 mg → Weeks 17–20: 12.5 mg → Weeks 21–72: 15 mg |
| Reconstitution Concentration | 1ml/10mg |
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038?utm_source=chatgpt.com
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