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Retatruitide
Retatruitide is an investigational 6 day injectable peptide being developed for treating obesity and metabolic diseases. It is the first triple hormone receptor agonist, meaning it simultaneously activates the GLP-1 (glucagon-like-peptide-1), GIP (glucose-dependent-insulinotropic-polypeptide), and glucagon receptors. This one of a kind mechanism reduces appetite, slows gastric emptying, improves insulin sensitivity, and increases energy expenditure, allowing it to target body weight through multiple metabolic pathways. During phase 2 clinical trial, a randomized, double blind, and placebo controlled study took place. Adults with obesity receiving the highest maintenance dose achieved an average 24.2% reduction in body weight after 48 weeks. Many participants continued to lose weight at the end of the study suggesting that maximal weight loss had not yet been reached.
| Study | Titration Schedule |
| 1mg | 1 mg weekly for all 48 weeks (no escalation) |
| 4mg (2mg start) | Weeks 1–4: 2 mg → Weeks 5–48: 4 mg |
| 4mg (4mg start) | 4 mg weekly from Week 1 |
| 8mg (2mg start) | Weeks 1–4: 2 mg → Weeks 5–8: 4 mg → Weeks 9–48: 8 mg |
| 8mg (4mg start) | Weeks 1–4: 4 mg → Weeks 5–48: 8 mg |
| 12mg (2mg start) | Weeks 1–4: 2 mg → Weeks 5–8: 4 mg → Weeks 9–12: 8 mg → Weeks 13–48: 12 mg |
| Reconstitution Concentration | 1ml/10mg |
https://www.nejm.org/doi/full/10.1056/NEJMoa2301972?utm_source
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